Selected Publications
T cell states, repertoire and function in classical Hodgkin lymphoma revealed through single-cell analyses
Xiufen Chen*, Jovian Yu*, Girish Venkataraman, Sonali M. Smith, Mengjie Chen, Alan Cooper, Sravya Tumuluru, Joshua D. Brody, James Godfrey, Justin Kline.
Cancer Immunol Res. 2024 Jan 19; published online.
*equal contribution.
![Screen Shot 2024-01-28 at 2.39.10 PM](https://klinelab.uchicago.edu/files/2024/01/Screen-Shot-2024-01-28-at-2.39.10-PM-50aa6db10bf589d6.png)
CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Brutonʼs Tyrosine Kinase Inhibition
Alan Cooper*, Sravya Tumuluru*, Kyle Kissick, Girish Venkataraman, Joo Y Song, Andrew Lytle, Gerben Duns, Jovian Yu, Nikita Kotlov, Aleksander Bagaev, Brendan Hodkinson, Srimathi Srinivasan, Sonali M Smith, David W Scott, Christian Steidl, James K Godfrey*, Justin Kline*.
J Clin Oncol. 2023 Dec 11; published online.
*equal contribution.
![Screen Shot 2023-12-13 at 10.41.16 AM](https://klinelab.uchicago.edu/files/2023/12/Screen-Shot-2023-12-13-at-10.41.16-AM.png)
Efficacy of checkpoint inhibition after CAR-T failure in aggressive B-cell lymphomas: outcomes from 15 US institutions
Ajay Major, Jovian Yu, Navika Shukla, Yan Che, Theodore G Karrison, Rachel Treitman, Manali K Kamdar, Bradley M Haverkos, James Godfrey, Melissa A Babcook, Timothy J Voorhees, Sophie Carlson, Daria Gaut, Caspian Oliai, Jason T Romancik, Allison M Winter, Brian T Hill, Radhika Bansal, Jose C Villasboas Bisneto, Imran A Nizamuddin, Reem Karmali, Lindsey A Fitzgerald, Deborah M Stephens, Priyanka A Pophali, Asaad Trabolsi, Jonathan H Schatz, Marie Hu, Veronika Bachanova, Michael J Slade, Nathan Singh, Nausheen Ahmed, Joseph P McGuirk, Michael R Bishop, Peter A Riedell, Justin Kline.
Blood Adv. 2023 Aug 22;7(16):4528-4538
![blooda_1712_Fx1_4c](https://klinelab.uchicago.edu/files/2023/08/blooda_adv-2023-010016-ga1-3.jpeg)
TIGIT is a key inhibitory checkpoint receptor in lymphoma
James Godfrey, Xiufen Chen, Nicole Sunseri, Alan Cooper , Jovian Yu , Arina Varlamova, Dmitry Zarubin, Yuriy Popov, Connor Jacobson, Ekaterina Postovalova, Zhongmin Xiang , Krystle Nomie, Aleksander Bagaev, Girish Venkataraman, Yuanyuan Zha, Sravya Tumuluru, Sonali M Smith, Justin Kline.
J Immunother Cancer. 2023 Jun;11(6):e006582
![jitc-2023-June-11-6--F5](https://klinelab.uchicago.edu/files/2023/07/jitc-2023-June-11-6-F5.jpg)
Pembrolizumab for the treatment of disease relapse after allogeneic hematopoietic stem cell transplantation
James Godfrey, Hongtao Liu, Jovian Yu, Michael Tallarico, Emily Curran, Andrew Artz, Peter A. Riedell, Wendy Stock, Theodore Karrison, Carrie Fitzpatrick, Girish Venkataraman, Alan Cooper, Sonali M. Smith, Michael R. Bishop, Justin Kline.
Blood Adv. 2023 Mar 2023;7(6):963–970
![m_blooda_adv-2022-008403-fx1](https://klinelab.uchicago.edu/files/2023/04/m_blooda_adv-2022-008403-fx1.jpeg)
Dendritic cells can prime anti-tumor CD8+ T cell responses through major histocompatibility complex cross-dressing
Brendan W MacNabb, Sravya Tumuluru, Xiufen Chen, James Godfrey, Darshan N Kasal, Jovian Yu, Marlieke LM Jongsma, Robbert M Spaapen, Douglas E Kline, Justin Kline.
Immunity. 2022 Jun 14;55(6):982-997.e8
![fx1_lrg](https://klinelab.uchicago.edu/files/2022/08/fx1_lrg.jpg)
Loss of 5-hydroxymethylcytosine expression is near-universal in B-cell lymphomas with variable mutations in epigenetic regulators
Kevin S Tanager, Jovian Yu, Brian CH Chiu, Timothy C Carll, Alexandra H Tatarian, Peter Riedell, Sonali Smith, Justin Kline, Girish Venkataraman.
Haematologica. 2022;107(4):966-969
![Screen Shot 2022-08-18 at 11.11.47 AM](https://klinelab.uchicago.edu/files/2022/08/Screen-Shot-2022-08-18-at-11.11.47-AM.png)
Antigen multimers: Specific, sensitive, precise, and multifunctional high-avidity CAR-staining reagents
Yifei Hu, Guoshuai Cao, Xiufen Chen, Xiaodan Huang, Nicholas Asby, Nicholas Ankenbruck, Ali Rahman, Ashima Thusu, Yanran He, Peter A Riedell, Michael R Bishop, Hans Schreiber, Justin Kline, Jun Huang.
Matter. 2021 Dec 1;4(12):3917-3940
![1-s2.0-S2590238521004999-fx1_lrg](https://klinelab.uchicago.edu/files/2022/08/1-s2.0-S2590238521004999-fx1_lrg.jpg)
Divergent fates of antigen-specific CD8+ T cell clones in mice with acute leukemia
Xiufen Chen, Brendan W MacNabb, Blake Flood, Bruce R Blazar, Justin Kline.
Cell Rep. 2021 Nov 9;37(6):109991
![1-s2.0-S2211124721014704-fx1_lrg](https://klinelab.uchicago.edu/files/2022/08/1-s2.0-S2211124721014704-fx1_lrg.jpg)
Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy in T-cell/histiocyte-rich large B-cell lymphoma
Jonathan A Trujillo, James Godfrey, Yifei Hu, Jun Huang, Sonali M Smith, Matthew J Frigault, Zachariah DeFilipp, Daniel Appelbaum, Yonglin Pu, Nicholas Feinberg, Thomas Althaus, Michael R Bishop, Peter A Riedell, Justin Kline.
Blood. 2021 Jun 17;137(24):3454-3459
![Screen Shot 2022-08-18 at 11.05.15 AM](https://klinelab.uchicago.edu/files/2022/08/Screen-Shot-2022-08-18-at-11.05.15-AM.png)
The immune landscape and response to immune checkpoint blockade therapy in lymphoma
Justin Kline, James Godfrey, Stephen M. Ansell.
Blood. 2020 Feb 20;135(8):523-533
![bloodbld2019000847absf1](https://klinelab.uchicago.edu/files/2021/01/bloodbld2019000847absf1.png)
PD-L1 gene alterations identify a subset of diffuse large B-cell lymphoma harboring a T-cell–inflamed phenotype
James Godfrey, Sravya Tumuluru, Riyue Bao, Michael Leukam, Girish Venkataraman, John Phillip, Carrie Fitzpatrick, James McElherne, Brendan W. MacNabb, Robert Orlowski, Sonali M. Smith, Justin Kline.
Blood. 2019 May 23;133(21):2279-2290
![blood879015absf1](https://klinelab.uchicago.edu/files/2021/01/blood879015absf1.png)
Negligible Role for Deletion Mediated by cDC1 in CD8 + T Cell Tolerance
Brendan W. MacNabb, Douglas E. Kline, Annie R. Albright, Xiufen Chen, Daniel S. Leventhal, Peter A. Savage and Justin Kline.
![batf3](https://klinelab.uchicago.edu/files/2021/02/batf3.jpg)
CD8α + Dendritic Cells Dictate Leukemia-Specific CD8 + T Cell Fates
Douglas E Kline, Brendan W MacNabb, Xiufen Chen, Wen-Ching Chan, Dominick Fosco, Justin Kline.
J Immunol. 2018 Dec 15;201(12):3759-3769
![nihms-1510113-f0005](https://klinelab.uchicago.edu/files/2021/02/nihms-1510113-f0005.jpg)
CD47 blockade by Hu5F9-G4 and rituximab in non-Hodgkin’s lymphoma
Ranjana Advani, Ian Flinn, Leslie Popplewell, Andres Forero, Nancy L Bartlett, Nilanjan Ghosh, Justin Kline, Mark Roschewski, Ann LaCasce, Graham P Collins, Thu Tran, Judith Lynn, James Y Chen, Jens-Peter Volkmer, Balaji Agoram, Jie Huang, Ravindra Majeti, Irving L Weissman, Chris H Takimoto, Mark P Chao, Sonali M Smith.
N Engl J Med. 2018 Nov 1;379(18):1711-1721
![Screen Shot 2022-08-18 at 3.21.35 PM](https://klinelab.uchicago.edu/files/2022/08/Screen-Shot-2022-08-18-at-3.21.35-PM.png)
Mechanisms of Immune Tolerance in Leukemia and Lymphoma
Emily K. Curran, James Godfrey, Justin Kline
Trends Immunol. 2017 Jul;38(7):513-525
![1-s2.0-S1471490617300753-gr1_lrg](https://klinelab.uchicago.edu/files/2022/08/1-s2.0-S1471490617300753-gr1_lrg.jpg)
Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia
Xiufen Chen, Dominick Fosco, Douglas E Kline, Justin Kline.
Oncoimmunology. 2017 Jan 10;6(4):e1278332
![koni-06-04-1278332-g003](https://klinelab.uchicago.edu/files/2021/02/koni-06-04-1278332-g003.jpg)
STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia
Emily Curran, Xiufen Chen, Leticia Corrales, Douglas E. Kline, Thomas W. Dubensky Jr., Priyanka Duttagupta, Marcin Kortylewski, Justin Kline.
Cell Rep. 2016 Jun 14;15(11):2357-66
![sting](https://klinelab.uchicago.edu/files/2021/02/fx1_lrg.jpg)
CD40 ligation reverses T cell tolerance in acute myeloid leukemia
Long Zhang, Xiufen Chen, Xiao Liu, Douglas E Kline, Ryan M Teague, Thomas F Gajewski, Justin Kline
J Clin Invest. 2013 May;123(5):1999-2010
![Screen Shot 2022-08-18 at 3.34.05 PM](https://klinelab.uchicago.edu/files/2022/08/Screen-Shot-2022-08-18-at-3.34.05-PM.png)